While in battle with Abomination and the Wrecking Crew, new Squaddie Reptil loses an Infinity Fractal. With both sides scrambling to retrieve it, Reptil, with Wolverine's help, learns to face his fears and what it means to be a hero. Meanwhile, Hulk inadvertently joins a mariachi band.

Silver Surfer is having a difficult time trying to fit in on Earth and chooses to leave the squad. Things get complicated when Dr. Doom kidnaps him.

During a chaotic battle with Klaw & Screaming Mimi, a fractal's cosmic power turns the Hulk into the Gray Hulk.

With supernatural wackiness plaguing the city, the Super Hero Squad enlists the help of the Sorcerer Supreme of the Earth dimension, Doctor Strange. However, the good doctor seems to be "off his rocker," babbling incoherently and summoning the Dread Dormammu to Super Hero City.

When the city is attacked, the squad investigates, only to find that a little girl named Brinny Bratten, who had a fractal stuck in her tiara, that gives her a large and terrifying power over reality. The Heroes For Hire are helping the Squad find her father, while Doom plans to use the chaos to his advantage.

Loki teams up with Doctor Doom in a plot to take over Asgard. Meanwhile, the latest Infinity Fractal causes Thor to lose his memory and it's up to Iron Man and Hulk to help him remember who he is.

A new villain named Scorpio shows up in superhero city. Nicky Fury disguises himself as a villain to infiltrate Doom's Headquarters to stop Dr. Doom from using a fractal to control a black hole.

When Falcon is presumed the cause of crashing The Helicarrier, The Squad is forced to relocate. Meanwhile, Enchantress and M.O.D.O.K. plan to attack Superhero City while the squad is tired from moving from place to place.

When MODOK and Abomination botched up another fractal retrieval mission, Doctor Doom pairs them up with Egghead in infiltrate the Helicarrier in micro-size. When Ant-Man is called in to help, it is a micro-sized, all-out battle for the fractal.