After the tragedy that awaited him in the city, Esteban Trueba leaves the desert and settles on the southern estate of Las Tres Marías, determined to forge an empire of his own. Meanwhile, Clara del Valle, guided by her mother Nívea and her Uncle Marcos, begins to awaken to a world of omens and hidden gifts. Two opposing paths cross, giving rise to a single family story.

Esteban brings Clara to their new home in the capital, "the big house on the corner." After their daughter Blanca is born, the family-including Esteban's sister, Férula-travels to Las Tres Marías, where Clara uncovers her husband's dark past and realizes her fate is bound to Pancha García and her descendants.

Blanca and Pedro Tercero, the foreman's son, grow up meeting every summer at Las Tres Marías. Their forbidden love deepens with each passing year, turning into a wild and dangerous passion. When Trueba discovers it, all the fury he had kept buried rises to the surface, threatening the safety of both his wife and his daughter.

Clara recovers from her husband's violence, thanks to the love and care of her astral sisters, Luisa, Nora, and Marta Mora. With them, she transforms the big house on the corner, following the advice of spirits to shelter the needy, artists, and seekers of spirituality. Meanwhile, Blanca survives Pedro's absence, embarking on a journey into the unknown.

Alba's birth softens old family wounds. Blanca profits from her ceramic beasts, unaware that her aunt Rosa first embroidered them decades earlier. Clara reaches her apogee alongside the Mora Sisters and her eccentric hosts, sharing laughter and spiritual knowledge, but a visit from the past brings Clara a new twist in her life.

At eighteen, Alba Trueba awakens to both passion and political conviction through her relationship with Miguel, as the country stands on a knife's edge between hope and division. Amid a crisis that reaches her own family, the revelation of a long-kept secret shakes her to the core, and the nation's political rupture will forever shape the course of her life.

The country faces a violent dictatorship, while the family is falling apart. Alba uses her privilege and does what she can to help those most in need, discovering that no one can escape their destiny.