Peter Cole is caught one night sleepwalking with a letter opener and standing over his wife's bed. His wife Doris is afraid and decides the next day to file for divorce. Exactly one year later, when the divorce is to be finalized, Frank Maddox, Peter's business partner, meets with Doris Cole. That night Frank Maddox spends the night at Peter Cole's house and exchanges bedrooms with Phillip Kendall, Peter's stepbrother. The next morning Phillip Kendall is found dead in bed and Peter Cole is accused of murder.

Sybil Granger hires Perry to help her buy stock in her estranged husband's oil company on the sly. By this, Sybil hopes to force her husband's latest girlfriend, Roxy Howard, out of the company and his life altogether. Things get complicated when George Lutts enters the picture and gets shot to death.

Donald Briggs is an unscrupulous private investigator hired by Clyde Waters to uncover information about Marv Adams, his daughter's fiancé. Later, Donald Briggs is found dead in his motel room, and Marv Adams is accused of the murder because he had a fight with Donald Briggs the previous morning.

Fran Celane feels her uncle, Edward Norton, is too restrictive as the executor of her father's spendthrift trust. He also wants her to wait 18 months until her 25th birthday before she gets married. Later, Norton is found dead and Rodney Gleason, Fran's fiancé, is identified as the perpetrator.

Harry Marlow owns a florist business and wants to own a part of Mildred Kimber's orchid business, but Mildred Kimber is not interested. So, Harry Marlow makes an arrangement with a local club owner, Sam Lynk, to cheat Mildred's husband, Bob Kimber, out of his share of the business in a card game. When Sam Lynk is found dead in his home, Mildred Kimber is accused of the crime.

Carla Adrian is having trouble fending off amorous neighbor Mark Cushing. When another neighbor hears a shot and a woman's scream, then witnesses Carla's Mother, Belle Adrian, in Mark Cushing's cabin—it's not long before the police discover Cushing’s body and arrest Mrs. Belle Adrian.

In a few day’s time, Fay Allison is getting married to Dane Grover. Her roommate, Anita Bonsal, is having a clandestine affair with a married man, Carver Clement. Fay Allison is later accused of Clement’s murder when the police find her fingerprints on a glass in his apartment.

Hollywood producer John Addison picks up an attractive young woman hitchhiker. Far from being innocent, she turns out to be a blackmailer—and a witness to a murder that Addison is charged with.

Ed Davenport learns that a sandwich he requested to be tested by a lab contains arsenic and blames his wife Myrna. When he confronts her about his suspicions, she denies it. He leaves for a business trip and falls ill. Dr. Renault is called to treat him at a motel where Ed Davenport later dies. Before he dies he claims his wife poisoned some candy.