A voodoo priestess animates her dead son to take revenge on the gangsters that killed him.

An invisible alien sucks out the bone marrow of its victims while it makes repairs on its spaceship and looks for directions home.

Catherine Rawlins, a female victim of Janos Skorzeny (the vampire from the original Night Stalker TV movie) is accidentally resurrected outside Las Vegas, and makes her way to Los Angeles. She takes up her old profession of call girl and Carl wrangles an assignment there to investigate.

Bernhardt Stieglitz, a NATO soldier bitten by a wolf, leaves a string of murder victims behind him. When Vincenzo is forced to abort his long-awaited vacation and report on the last cruise of an ocean liner, the USS Hanover, Carl takes his place, only to find that Stieglitz is one of the passengers on board...and the full moon is rising. Trapped aboard the liner, Kolchak must use a shotgun and silver buckshot to kill the creature once and for all.

A series of mysterious deaths plague the life of conductor Ryder Bond. In each case, the victim is incinerated by supernaturally hot flames. As Kolchak investigates, he finds out that an arsonist, Frankie Markoff, was a fan of Bond's, and was killed in a penny arcade. His funeral procession crossed Bond's car, allowing the spirit to become a ""doppelganger"" and try to take over Bond's life. Each victim was burned to death when they fell asleep, and if Bond goes to sleep the doppelganger will take him over for good. Fighting sleep himself, Kolchak must exhume Markoff's body and reunite it with his restless spirit before he too bursts into flame.

Kolchak discovers a young rising politician, has made a deal with the Devil to murder off his competition through incidents made to look like accidents.

A series of suicides among high-society matrons coincides with a bizarre jewel theft by a towering Indian who mysteriously disappears when cornered. Kolchak investigates and finds that the Indian is a ""diablero,"" a cursed cliff-dwelling Indian medicine man condemned to walk the earth gathering an eternal horde of jewels. The diablero can change shape into the form of a coyote or crow, and hypnotize anyone with its eyes. Carl must seek the diablero in the highest place he can find, and turn the power of its eyes against it.

A series of apparently unrelated deaths involve each victim being crushed to death, and covered in wet, slimy Spanish Moss. Upon investigation, Kolchak discovers that each victim was related to Paul Langois, a hot-tempered Cajun. However, Langois has an iron-clad alibi: he's been the subject of a sleep experiment and been kept asleep for several weeks. Eventual, Carl realizes that somehow Langois' sleep state has caused him to manifest a subconscious ""boogey-man"" from the Cajun bayou: Peremalfait, a huge creature covered in Spanish Moss that crushes the life right out of you. Peremalfait ""kills"" Langois to prevent him from being woken up, and Kolchak must travel into the sewers of Chicago to kill Peremalfait with the only thing that can destroy it: a spear made out of bayou gum wood.

Several Indian construction workers are killed during high-rise work on a new hospital. They leave the job, and the hospital is completed. However, a series of strange electrocutions continue to plague the hospital after its grand opening. Kolchak investigates and finds that a ""bear-god"" spirit, Matchemonedo, was resurrected from its burial spot beneath Lake Michigan by the hospital construction. Now the creature, which feeds on energy, is beginning to awaken. Kolchak must convince the hospital officials to re-refrigerate the ""bear-god"" and drive it back into hibernation before it awakens once and for all.