On the run and in desperate need of money, Tate takes Bo to Atlantic City, where she instantly bonds with a struggling mother and her sick child. The involvement of the FBI complicates Skouras' efforts to covertly recover Bo, while Winter and Channing work to stay one step ahead.

Trapped in Manhattan, Bo and Tate encounter a wealthy woman mourning the decades-old loss of her son.

As the dragnet closes, Tate puts his freedom at risk to help Bo find the writer of a long-lost love letter. Meanwhile, Winter makes preparations for an escape from Manhattan as Skouras and Agent Ferrell ramp up the effort to bring Tate and Bo into custody.

Bo and Tate resurface in Philadelphia where Bo is drawn toward a young woman and her husband, a blogger whose unrelenting pursuit of a mysterious story is threatening to tear the couple apart. Meanwhile, Skouras takes forceful action to track down a traitor within Orchestra.

With Bo, Winter and Channing in pursuit, Tate travels home to seek out the childhood friends who framed him for murder. Meanwhile at the Orchestra campus, Skouras focuses his attention on the potential of a young telepath.

After an intense confrontation with Zepeda leaves Bo vulnerable, Winter turns to guardians from Bo's past to protect her once again. As Tate and Winter take risky action to help Bo, revisiting the girl's past reveals surprising information about Channing's history. At Orchestra, Skouras pushes Sean to control his telekinetic abilities, with dangerous results.

Worried that Skouras has developed the ability to locate Bo, Winter sends Channing on a mission to infiltrate the Orchestra campus. Despite Winter's instructions to keep a low profile, Bo is compelled to help a family man who is in over his head.

Tate's efforts to keep Bo focused on her training are sidetracked when Bo has a premonition of a young musical prodigy dying in a car crash. In the wake of Channing's capture, Winter sets a risky contingency plan in motion. At Orchestra, Skouras tests the powers of Dani, a newly discovered telepath.

When Bo has a premonition of a tragic event in the New York City subway, she convinces Tate to help her in stopping her vision from becoming reality. A confrontation with FBI Agent Ferrell in the subway station quickly changes course when an explosion leaves them trapped underground. Meanwhile, Dani proves herself to Skouras as she settles into her new home at Orchestra.