Professor Utonium falls head-over-heels in love for the lovely Ima Goodlady. Unfortunately, she's really the sinister Sedusa, out to keep the Girls grounded for the first time ever while she commits crimes around Townsville, such as making off with the Mayor's jewels.

The Powerpuff Girls hate roaches. Roach Coach uses this to his advantage to take over Townsville. Can the Powerpuff Girls overcome their fear of roaches?

After putting 3 criminals to jail those 3 criminals dress up as the Powerpuff Girls. Spreading crime wherever they go these impostors ruin the girls' reputation.

The heinous Him toys with Bubbles' mind by speaking to her through Octi, her favorite stuffed animal. Following Octi/Him's instructions, Bubbles provokes a fight between her sisters that prompts the Professor to issue a time-out until the Girls can make amends and make squid meat out of the giant, Him-controlled Octi.

The Amoeba Boys' ill-conceived plan to stand in front of the "Keep off the Grass" sign at Townsville Park all night in the rain leaves them with a terrible virus. When they infect the Townsville population, it's up to the Girls to find the antidote.

Buttercup becomes smitten with Ace, the leader of the Ganggreen Gang. However, when the gang exploits her infatuation and lures Blossom and Bubbles into danger, Buttercup quickly comes to her sisters' rescue and shows the boys the real meaning of the word "crush."

A squirrel trespasses on Fuzzy Lumpkins private property. Fuzzy chases him all the way into Townsville and goes crazy hurting all the citizens that stand in his way.

When all the lights go out at night the Boogie Man and his monsters come out to boogie all night long.

The Mayor tells the girls' a story about a famous magician who died by a trick with a laughing audience. Now the magician has come back to life to take out his revenge.